Longitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression
Autor: | Lieke Martens, Iris Dalhuisen, Eveline Ackermans, Jan Spijker, Peter F.A. Mulders, Philip van Eijndhoven, Alex de Bruijn, Joey Bartholomeus, Indira Tendolkar |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_treatment Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Medizin Hippocampus Hippocampal formation Paralimbic cortex Experimental Psychopathology and Treatment Depressive Disorder Treatment-Resistant 0302 clinical medicine Dorsolateral Prefrontal Cortex rTMS Pharmacology (medical) Neuronal Plasticity Depression 220 Statistical Imaging Neuroscience General Medicine Middle Aged Amygdala Transcranial Magnetic Stimulation Psychiatry and Mental health medicine.anatomical_structure Treatment Outcome Cingulate gyrus Cardiology Major depressive disorder Female psychological phenomena and processes medicine.medical_specialty Cortical thickness 03 medical and health sciences Internal medicine Neuroplasticity medicine Humans Biological Psychiatry Depressive Disorder Major Original Paper business.industry medicine.disease 030227 psychiatry Transcranial magnetic stimulation nervous system business Treatment-resistant depression 170 000 Motivational & Cognitive Control 030217 neurology & neurosurgery |
Zdroj: | European Archives of Psychiatry and Clinical Neuroscience, 271, 1, pp. 39-47 European Archives of Psychiatry and Clinical Neuroscience European Archives of Psychiatry and Clinical Neuroscience, 271, 39-47 |
ISSN: | 1553-5800 0940-1334 |
Popis: | Major depressive disorder (MDD) is amongst the most prevalent of psychiatric disorders. Unfortunately, a third of patients will not respond to conventional treatments and suffer from treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) has been proven effective in treating TRD. The research suggests that rTMS acts via neuroplastic effects on the brain, which can be measured by changes in hippocampal and amygdala volume as well as cortical thickness. This sham-controlled study investigates longitudinal effects of rTMS on the volumes of the hippocampus and amygdala and cortical thickness in patients with chronic TRD. 31 patients received 20 sessions of high-frequency rTMS (N = 15) or sham treatment (N = 16) over the left dorsolateral prefrontal cortex during 4 consecutive weeks. Using structural magnetic resonance imaging, we investigated longitudinal treatment effects on hippocampus and amygdala volume as well as thickness of the paralimbic cortex. We found no clinical differences between the active and sham rTMS group. Longitudinal changes in hippocampal and amygdala volume did not differ significantly, although males showed a significant decrease in left amygdala volume, irrespective of treatment group. Changes in cortical thickness of the paralimbic cortex differed significantly between the active and sham groups. Most notably, the increase in cortical thickness of the isthmus of the left cingulate gyrus was greater in the active as compared to the sham rTMS group. Our data suggest that rTMS can induce neuroplastic changes, particularly in cortical thickness, independent of treatment response. We also found longitudinal changes in amygdala volume in males. For clinical effects to follow these neuroplastic effects, more intensive rTMS treatment might be needed in chronically depressed patients. Trial registration number: ISRCTN 15535800, registered on 29-06-2017. Electronic supplementary material The online version of this article (10.1007/s00406-020-01135-w) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
Externí odkaz: |