Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication
| Autor: | Simon Lovestone, Sophia Rabe-Hesketh, A Giora, D L Oliver, Simon Fleminger |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Paper medicine.medical_specialty Disease Alzheimer Disease Risk Factors Internal medicine Correspondence Epidemiology Odds Ratio medicine Craniocerebral Trauma Humans Risk factor business.industry Head injury Absolute risk reduction Case-control study Reproducibility of Results Odds ratio medicine.disease Surgery Psychiatry and Mental health Case-Control Studies Female Neurology (clinical) Alzheimer's disease business |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 74:857-862 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.74.7.857 |
| Popis: | Objective: To determine, using a systematic review of case-control studies, whether head injury is a significant risk factor for Alzheimer’s disease. We sought to replicate the findings of the meta-analysis of Mortimer et al (1991). Methods: A predefined inclusion criterion specified case-control studies eligible for inclusion. A comprehensive and systematic search of various electronic databases, up to August 2001, was undertaken. Two independent reviewers screened studies for eligibility. Fifteen case-control studies were identified that met the inclusion criteria, of which seven postdated the study of Mortimer et al . Results: We partially replicated the results of Mortimer et al . The meta-analysis of the seven studies conducted since 1991 did not reach significance. However, analysis of all 15 case-control studies was significant (OR 1.58, 95% CI 1.21 to 2.06), indicating an excess history of head injury in those with Alzheimer’s disease. The finding of Mortimer et al that head injury is a risk factor for Alzheimer’s disease only in males was replicated. The excess risk of head injury in those with Alzheimer’s disease is only found in males (males: OR 2.29, 95% CI 1.47 to 2.06; females: OR 0.91, 95% CI 0.56 to 1.47). Conclusions: This study provides support for an association between a history of previous head injury and the risk of developing Alzheimer’s disease. |
| Databáze: | OpenAIRE |
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