Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of α7 nicotinic receptor, glutamate and oxidative stress
| Autor: | Leda Giannuzzi, Sergio Dominguez, María del Carmen Esandi, Alejandra Minetti, Cristina Bras, Fernanda Gumilar, Cecilia Bouzat, Cristina Eugenia Gallegos, Mariana Bartos, Nina Mónaco |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
alpha7 Nicotinic Acetylcholine Receptor Excitotoxicity Hippocampus Toxicology medicine.disease_cause GLUTAMATE 0302 clinical medicine Α7-NICOTINIC RECEPTOR Glutamates Pregnancy Lactation OXIDATIVE STRESS biology Chemistry General Neuroscience Glutamate receptor purl.org/becyt/ford/3.1 [https] Química Sodium Compounds Medicina Básica medicine.anatomical_structure Catalase Prenatal Exposure Delayed Effects Female purl.org/becyt/ford/3 [https] ARSENIC medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Offspring Arsenites Glutamic Acid Α7-NICOTINIC RECEPTOR 03 medical and health sciences FEMALE RATS Internal medicine Toxicología medicine Animals Female rats Rats Wistar Ciencias Exactas Memory Disorders Arsenic α7-nicotinic receptor medicine.disease Rats 030104 developmental biology Endocrinology Oxidative stress biology.protein 030217 neurology & neurosurgery |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg/L). In 90-day-old female offspring, short-term memory (STM) and long-term memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the α7 nicotinic receptor (α7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity. Centro de Investigación y Desarrollo en Criotecnología de Alimentos |
| Databáze: | OpenAIRE |
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