The Effect of Antibiotics, Primary and Secondary Closure on Clostridial Contaminated Open Fracture Wounds in Rats
| Autor: | Daniel Ivler, Michael J. Patzakis, Lawrence D. Dorr, William Hammond |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Open fracture Clostridium perfringens medicine.drug_class Antibiotics Penicillins Thigh Critical Care and Intensive Care Medicine medicine.disease_cause Fractures Bone Cephalothin medicine Animals Femur fracture business.industry Mortality rate Rats Surgery Tibial Fractures Penicillin medicine.anatomical_structure Clostridium Infections Wound Infection Female business Femoral Fractures Anaerobic exercise medicine.drug |
| Zdroj: | The Journal of Trauma: Injury, Infection, and Critical Care. 18:34-37 |
| ISSN: | 0022-5282 |
| Popis: | In a study of experimentally induced open tibial or femoral fractures in rats, after either closing or leaving the wounds open, the animals were given: no antibiotic, cephalothin (Keflin), or penicillin. The rats with wounds closed primarily and receiving no antibiotics had the highest mortality rate (11 of 25) from experimentally produced clostridial myonecrosis. The lowest overall mortality rate (5 of 99) was found in the penicillin-treated groups. The higher mortality rate in the femur fracture groups was probably because of the large muscle mass of the thigh. The importance of ideal anaerobic conditions for producing experimental clostridial myonecrosis is emphasized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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