FGF21 Regulates Sweet and Alcohol Preference
| Autor: | Parkyong Song, Bryan Goodwin, Bhavna S. Paratala, Steven A. Kliewer, Yuan Zhang, Barbara Bernardo, Yingjiang Zhou, Saswata Talukdar, Christian P. Müller, David J. Mangelsdorf, William T. Scott, Bryn M. Owen, Tod Turner, Genaro Hernandez, Andrew H. Smith, Hao Tang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Taste FGF21 Physiology 030209 endocrinology & metabolism Cell Biology Biology Nucleus accumbens medicine.disease Obesity Energy homeostasis 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology chemistry Dopamine Internal medicine medicine Molecular Biology Saccharin medicine.drug Hormone |
| Zdroj: | Cell Metabolism. 23:344-349 |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2015.12.008 |
| Popis: | Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans. |
| Databáze: | OpenAIRE |
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