Antihypertensive effects of Ocimum gratissimum extract: Angiotensin-converting enzyme inhibitor in vitro and in vivo investigation
| Autor: | Ming-Shyong Wang, Jhih-Ling Wu, Huey-Mei Shaw |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Spontaneously hypertensive rats (SHRs)
Rutin Medicine (miscellaneous) Pharmacology 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology 0302 clinical medicine In vivo ACE inhibitor medicine TX341-641 cardiovascular diseases IC50 chemistry.chemical_classification Nutrition and Dietetics biology Ocimum gratissimum (OG) Nutrition. Foods and food supply Ocimum gratissimum Angiotensin-converting enzyme 04 agricultural and veterinary sciences biology.organism_classification Angiotensin-converting enzyme (ACE) 040401 food science In vitro Enzyme chemistry 030220 oncology & carcinogenesis biology.protein Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 35, Iss, Pp 68-73 (2017) |
| ISSN: | 1756-4646 |
| Popis: | This study aimed to examine whether Ocimum gratissimum (OG) has the Angiotensin-converting enzyme (ACE) inhibitory activity in vitro and in spontaneously hypertensive rats (SHRs). OG water extract exhibited an in vitro ACE-inhibition activity, with the 50% inhibition concentration (IC50) value being 56.3 μg/mL, which is higher than rutin’s 43.08 μg/mL. The main phenolic compound found in OG extract was rutin, according to the HPLC fractionation profile. The anti-hypertension effect in vivo was tested with SHRs. SHRs were fed orally with a distilled water, 100 or 500 mg/kg BW OG extract for 8 weeks. Systolic blood pressure, ACE levels in plasma and lung, and plasma endothelin-1 were significantly lower in the 500 mg/kg OG group compared with the SHRs group. These results suggested that OG extract has the ACE inhibition activity in vitro and also in SHRs, which may be due to its main component of phenolic compound, rutin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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