Early corticosteroids requirement after the diagnosis of ulcerative colitis diagnosis can predict a more severe long-term course of the disease - a nationwide study of 1035 patients

Autor:	Nabeel Khan, R. M. Almukhtar, Ali Abbas, Elisabeth B. Cole
Rok vydání:	2014
Předmět:	Adult Male medicine.medical_specialty Time Factors medicine.medical_treatment Population Severity of Illness Index Cohort Studies Internal medicine Humans Medicine Pharmacology (medical) education Glucocorticoids Veterans Affairs Colectomy Survival analysis Aged Proportional Hazards Models Retrospective Studies education.field_of_study Predictive marker Hepatology business.industry Gastroenterology Retrospective cohort study Middle Aged Survival Analysis Surgery Cohort Disease Progression Regression Analysis Colitis Ulcerative Female business Follow-Up Studies Cohort study
Zdroj:	Alimentary Pharmacology & Therapeutics. 40:374-381
ISSN:	0269-2813
Popis:	Summary Background There are limited data regarding clinical outcomes in ulcerative colitis (UC) patients who require early corticosteroids (CS) use. Aim To evaluate the rate of early CS utilisation (within 30 days of diagnosis) as a predictive marker for long-term outcomes, colectomy and CS dependency, in a population-based cohort of incident UC cases. Methods Nationwide data were obtained from the Veterans Affairs (VA) health care system for the period 2001–2011. Incident UC cases were identified. A retrospective cohort design and time-to-event survival analysis were used to track outcomes of interest. Cox regression multivariate analysis was employed. Results One thousand and thirty-five newly diagnosed patients with UC were identified and included in the analysis; 236 (23%) of those patients required early CS therapy. Patients were followed-up over a median time of 4.7 years (IQR 2.8–6.8) after UC diagnosis. The 5-year cumulative probability of requiring colectomy varied significantly by early CS use status (13% among early CS users compared to 4% among those who did not require early CS treatment, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d008a4ea8abc52ad7d5ef49d2ccd9764 https://doi.org/10.1111/apt.12834 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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