Transmammary modulation of xenobiotic metabolizing enzymes in liver of mouse pups by mace (Myristica fragrans Houtt.)
| Autor: | A. Ramesha Rao, Saranjit K. Chhabra |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Glutathione reductase omega-Chloroacetophenone Omega-Chloroacetophenone Myristicaceae chemistry.chemical_compound Mice Mammary Glands Animal Cytochrome P-450 Enzyme System Pregnancy Internal medicine Drug Discovery medicine Animals Anticarcinogenic Agents Lactation cardiovascular diseases Sulfhydryl Compounds Glutathione Transferase Pharmacology chemistry.chemical_classification Glutathione Peroxidase Plants Medicinal biology Plant Extracts Glutathione peroxidase Glutathione biology.organism_classification Endocrinology Cytochromes b5 Glutathione Reductase chemistry Liver biology.protein Myristica fragrans Female Mace Peroxidase |
| Zdroj: | Journal of ethnopharmacology. 42(3) |
| ISSN: | 0378-8741 |
| Popis: | The present study examines the possible transfer of the active principle(s) of mace (aril of the plant Myristica fragrans) through the transmammary route and its ability to modulate hepatic xenobiotic metabolizing enzymes in the F1 progeny of mice. An aqueous suspension of mace at the dose levels of 0.025 or 0.1 g/animal/day was administered by oral gavage to dams from day 1 of lactation and continued daily for 14 or 21 days. Dams receiving mace treatment and their F1 pups showed significantly elevated hepatic sulfhydryl content, glutathione S-transferase and glutathione reductase activities and cytochrome b5 content. Hepatic cytochrome P450 content decreased in dams (P < 0.05) receiving the lower mace dose for 21 days and the F1 pups (P < 0.001), but increased in dams receiving the higher dose for both time periods (P < 0.001) and the lower dose for 14 days (P < 0.05). Only the 14-day-old pups of dams receiving either mace dose showed significantly elevated (P < 0.001) levels of hepatic glutathione peroxidase. |
| Databáze: | OpenAIRE |
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