Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration
| Autor: | Anna Scislowska-Czarnecka, Marcin Gajek, Piotr Szatkowski, Ewa Dzierzkowska, Kamil Kornaus, Magdalena Chadzinska, Maciej Boguń, Marcin H. Kudzin, Ewa Stodolak-Zych |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Scaffold
Materials science Morphology (linguistics) lcsh:Biotechnology nonwoven tissue engineering scaffolds Biomedical Engineering wound healing 02 engineering and technology Calorimetry 010402 general chemistry 01 natural sciences skin tissue engineering Article law.invention Biomaterials chemistry.chemical_compound Polylactic acid law Poly(lactide) acid lcsh:TP248.13-248.65 Fiber melt-blown nonwoven Crystallization Composite material Porosity lcsh:R5-920 poly(lactide) acid 021001 nanoscience & nanotechnology 0104 chemical sciences Lactic acid chemistry lcsh:Medicine (General) 0210 nano-technology |
| Zdroj: | Journal of Functional Biomaterials Volume 12 Issue 1 Pages: 16 Journal of Functional Biomaterials, Vol 12, Iss 16, p 16 (2021) |
| ISSN: | 2079-4983 |
| Popis: | Skin regeneration requires a three-dimensional (3D) scaffold for cell adhesion, growth and proliferation. A type of the scaffold offering a 3D structure is a nonwoven material produced via a melt-blown technique. Process parameters of this technique can be adapted to improve the cellular response. Polylactic acid (PLA) was used to produce a nonwoven scaffold by a melt-blown technique. The key process parameters, i.e., the head and air temperature, were changed in the range from 180–270 °C to obtain eight different materials (MB1–MB8). The relationships between the process parameters, morphology, porosity, thermal properties and the cellular response were explored in this study. The mean fiber diameters ranged from 3 to 120 µm. The average material roughness values were between 47 and 160 µm, whereas the pore diameters ranged from 5 to 400 µm. The calorimetry thermograms revealed a correlation between the temperature parameters and crystallization. The response of keratinocytes and macrophages exhibited a higher cell viability on thicker fibers. The cell-scaffold interaction was observed via SEM after 7 days. This result proved that the features of melt-blown nonwoven scaffolds depended on the processing parameters, such as head temperature and air temperature. Thanks to examinations, the most suitable scaffolds for skin tissue regeneration were selected. |
| Databáze: | OpenAIRE |
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