Liver stiffness measurements by 2-dimensional shear wave elastography compared to histological and ultrasound parameters in primary biliary cholangitis
| Autor: | Ilias Gatos, Peter Drazinos, John Ketikoglou, Irene Vafiadis, Emanuel K. Manesis, Maria Schina, Ioanna Delladetsima, John Theotokas, Dina Tiniakos, Pavlos Zoumpoulis |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Shear wave elastography Cirrhosis medicine.diagnostic_test Liver Cirrhosis Biliary business.industry Ultrasound Gastroenterology Hepatology medicine.disease Liver stiffness Internal medicine Liver biopsy Cohort Elasticity Imaging Techniques Humans Medicine Female Elastography business Retrospective Studies |
| Zdroj: | Scandinavian Journal of Gastroenterology. 56:1187-1193 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | BACKGROUND AND AIMS Liver stiffness measurements (LSMs) by 2-dimensional-shear-wave elastography (LSM2D-SWE) are now widely used in hepatology. However, relevant information for primary biliary cholangitis (PBC) is scant. We compare LSM2D-SWE with liver biopsy (LB) in a cohort of PBC patients in Greece. METHODS Data of 68 LBs from 53 PBC patients were retrospectively analyzed and fibrosis stage was compared to LSM2D-SWE. Forty-six patients (86.8%) were females and at the time of LBx median (IQR) age was 62.6 (53.2-72.1). Demographic, UDCA treatment, histological and B-mode ultrasound data were tested for their influence on LSM2D-SWE estimates. RESULTS Liver fibrosis stages F0-F4 were found in 4, 19, 19, 16 and 10 cases, respectively. Across stages F0-F4, the LSM2D-SWE was 5.6 (5.1-6.1), 7.0 (5.8-7.7), 9.1 (7.3-11.5), 10.8 (9.9-12.2) and 14.5 (11.9-25.7) kPa, respectively, with highly significant difference (p |
| Databáze: | OpenAIRE |
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