Comprehensive analysis of the expression and prognosis for S100 in human ovarian cancer
| Autor: | Quan Zhou, Hua-Mei Song, Hong-Yu Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Observational Study S100 family Carcinoma Ovarian Epithelial medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Text mining Internal medicine Databases Genetic Kaplan–Meier plotter Carcinoma Humans Medicine Genetic Predisposition to Disease RNA Messenger 030212 general & internal medicine Stage (cooking) Pathological Survival analysis Neoplasm Staging Mutation biology business.industry S100 Proteins S100A10 General Medicine Prognosis medicine.disease Survival Analysis ovarian cancer 030220 oncology & carcinogenesis biology.protein Female Neoplasm Grading business Ovarian cancer signature Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000022777 |
| Popis: | S100 family members are frequently deregulated in human malignancies, including ovarian cancer. However, the prognostic roles of each individual S100 family member in ovarian cancer (OC) patients remain elusive. In the present study, we assessed the prognostic roles and molecular function of 20 individual members of the S100 family in OC patients using GEPIA, Kaplan–Meier plotter, SurvExpress, GeneMANIA and Funrich database. Our results indicated that the mRNA expression levels of S100A1, S100A2, S100A4, S100A5, S100A11, S100A14, and S100A16 were significantly upregulated in patients with OC, and high mRNA expression of S100A1, S100A3, S100A5, S100A6, and S100A13 were significantly correlated with better overall survival, while increased S100A2, S100A7A, S100A10, and S100A11 mRNA expressions were associated with worse prognosis in OC patients. In stratified analysis, the trends of high expression of individual S100 members were nearly the same in different pathological grade, clinical stage, TP53 mutation status, and treatment. More importantly, S100 family signatures may be useful potential prognostic markers for OC. These findings suggest that S100 family plays a vital role in prognostic value and could potentially be an S100-targeted inhibitors for OC patients. |
| Databáze: | OpenAIRE |
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