Outcome of patients with primary immune-complex type mesangiocapillary glomerulonephritis (MCGN) in Cape Town South Africa

Autor: Ikechi G. Okpechi, George Moturi, Maureen Duffield, Charles R. Swanepoel, Brian Rayner, Thandiwe A. L. Dlamini
Přispěvatelé: Division of Nephrology and Hypertension, Faculty of Health Sciences
Rok vydání: 2013
Předmět:
Male
Biopsy
lcsh:Medicine
Blood Pressure
Kidney
Vascular Medicine
chemistry.chemical_compound
South Africa
Chronic Kidney Disease
Medicine and Health Sciences
Medicine
lcsh:Science
Prospective cohort study
Multidisciplinary
medicine.diagnostic_test
Middle Aged
Prognosis
Proteinuria
Nephrology
Creatinine
Hypertension
Female
Glomeruli
Immunosuppressive Agents
Glomerular Filtration Rate
Research Article
Adult
medicine.medical_specialty
Histology
Complement system
Glomerulonephritis
Membranoproliferative
Renal function
End stage renal disease
Young Adult
Internal medicine
Medical Dialysis
Humans
Retrospective Studies
business.industry
Proportional hazards model
lcsh:R
Retrospective cohort study
medicine.disease
Fibrosis
Surgery
chemistry
Tubulointerstitial Disease
Kidney Failure
Chronic
lcsh:Q
business
Kidney disease
Zdroj: PLoS ONE
PLoS One
PLoS ONE, Vol 9, Iss 11, p e113302 (2014)
ISSN: 1932-6203
Popis: Background and Aim Mesangiocapillary glomerulonephritis (MCGN) is a common cause of chronic kidney disease in developing countries. Data on the renal outcome of patients with idiopathic MCGN is limited. The aim of this study is to investigate the outcome of patients with idiopathic MCGN presenting to the Groote Schuur Hospital (GSH) Renal Unit in Cape Town. Materials and Methods A retrospective study of patients with idiopathic MCGN followed up at our clinic. Seventy-nine patients with no identifiable cause of MCGN were included for analysis. A composite renal outcome of persistent doubling of serum creatinine or end stage renal disease (ESRD) was used. Kaplan Meier survival and Cox regression analysis were used to assess survival and identify factors predicting the outcome. Results The mean age at biopsy was 33.9±13.6 years and 41.8% were black. Mean duration of follow up was 13.5±18.8 months. Twenty-three patients (34.2%) reached the composite endpoint. Overall, median renal survival was 38.7±11.7 months (95% CI 15.7–61.8) with 2-year and 5-year renal survival of 61% and 40.3% respectively. No significant difference was found for renal survival between males and females, treatment or non-treatment with immunosuppression, presence or absence of crescents or histological type of MCGN (p>0.05). On univariate Cox-regression analysis, factors found to be associated with the outcome were the estimated glomerular filtration rate at biopsy (OR 0.97 [95%CI: 0.95–0.99], p
Databáze: OpenAIRE
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