Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)

Autor:	Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki
Rok vydání:	2022
Předmět:	Metals and Alloys General Chemistry Histone Deacetylases Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Histone Deacetylase Inhibitors Repressor Proteins Jurkat Cells Drug Discovery Proteolysis Materials Chemistry Ceramics and Composites Humans
Zdroj:	Chemical Communications. 58:4635-4638
ISSN:	1364-548X 1359-7345
Popis:	We developed a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8). The PROTAC induced degradation of HDAC8 without affecting the levels of other HDACs in cellular assays, and inhibited the growth of T-cell leukemia Jurkat cells more potently than a conventional HDAC8 inhibitor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffcc6c0229a2e996a3337b238f808be https://doi.org/10.1039/d2cc00272h Zobrazit plný text záznamu