Decreased functional connectivity in patients with major depressive disorder and a history of childhood traumatization through experiences of abuse

Autor: Saskia Thérèse, Schirmer, Fienne-Elisa, Beckmann, Hanna, Gruber, Konstantin, Schlaaff, Denise, Scheermann, Stephanie, Seidenbecher, Coraline Danielle, Metzger, Claus, Tempelmann, Thomas, Frodl
Rok vydání: 2023
Předmět:
Zdroj: Behavioural Brain Research. 437:114098
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2022.114098
Popis: Childhood trauma (CT) increases vulnerability for the development of major depressive disorder (MDD). Alterations in resting-state functional connectivity (RSFC) have frequently been reported for MDD. These alterations may be much more prominent in depressive patients with a history of CT. The present study aims to compare RSFC in different brain networks of patients with MDD and CT (MDD+CT) vs. MDD and no CT compared to healthy controls.45 patients (22 with CT) were compared to 23 age-and-gender-matched healthy control subjects. Demographic parameters, severity of MDD, severity of CT and comorbid anxiety disorders were assessed. For assessment of RSFC alterations, a seed-based approach within five well-established RSFC networks was used.CT in MDD patients predicts severity of comorbid anxiety. A significant decrease in in-between network RSFC-values of MDD patients compared to controls was found in the network pairs of default mode network (DMN) - dorsal attention network (DAN), ventral attention network (VAN) - DMN and DAN - affective network (AN). MDD+CT patients presented more aberrant RSFC than MDD-CT patients. MDD scores predicted the decrease in RSFC for MDD patients. Higher Childhood Trauma Questionnaire (CTQ) scores are linked to reduced functional connectivity (FC) between DMN - DAN.Our study shows reduced RSFC in MDD patients for DMN - DAN, VAN - DMN, DAN - AN and MDD+CT patients presented more aberrant RSFC so that we suspect CT to be a considerable factor in the etiology of MDD. Through dysregulated neural circuits, CT is likely to contribute to a distinct MDD pathophysiology.
Databáze: OpenAIRE
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