Virological Surveillance of Influenza A Subtypes Isolated in 2014 from Clinical Outbreaks in Canadian Swine
| Autor: | Zvonimir Poljak, Helena Grgić, Jackie Gallant |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Canada influenza A virus triple-reassortant H3N2 H1N2 swine genome Swine viruses 030106 microbiology Biology medicine.disease_cause Disease cluster Genome Article Virus Disease Outbreaks 03 medical and health sciences Antigenic Diversity Orthomyxoviridae Infections Virology Influenza A virus medicine Animals Cluster Analysis Phylogeny Swine Diseases Molecular Epidemiology Phylogenetic tree Host (biology) Genetic Variation Outbreak Antigenic Variation 030104 developmental biology Infectious Diseases Epidemiological Monitoring |
| Zdroj: | Viruses Viruses; Volume 9; Issue 3; Pages: 55 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v9030055 |
| Popis: | Influenza A viruses (IAVs) are respiratory pathogens associated with an acute respiratory disease that occurs year-round in swine production. It is currently one of the most important pathogens in swine populations, with the potential to infect other host species including humans. Ongoing research indicates that the three major subtypes of IAV—H1N1, H1N2, and H3N2—continue to expand in their genetic and antigenic diversity. In this study, we conducted a comprehensive genomic analysis of 16 IAVs isolated from different clinical outbreaks in Alberta, Manitoba, Ontario, and Saskatchewan in 2014. We also examined the genetic basis for probable antigenic differences among sequenced viruses. On the basis of phylogenetic analysis, all 13 Canadian H3N2 viruses belonged to cluster IV, eight H3N2 viruses were part of the IV-C cluster, and one virus belonged to the IV-B and one to the IV-D cluster. Based on standards used in this study, three H3N2 viruses could not be clearly classified into any currently established group within cluster IV (A to F). Three H1N2 viruses were part of the H1α cluster. |
| Databáze: | OpenAIRE |
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