Peroxisome proliferator activated receptor (PPAR)-gamma concentrations in childhood obesity

Autor:	Nesibe Akyürek, Zehra Aycan, Sebahat Yılmaz Ağladıoğlu, Semra Çetinkaya, Ulker Ertan, Ömer Akyürek
Rok vydání:	2013
Předmět:	Blood Glucose Male Pediatric Obesity medicine.medical_specialty Adolescent medicine.medical_treatment Clinical Biochemistry Peroxisome proliferator-activated receptor Blood Pressure Childhood obesity Body Mass Index Insulin resistance Internal medicine medicine Humans Insulin Child chemistry.chemical_classification medicine.diagnostic_test business.industry General Medicine Venous blood medicine.disease Lipids PPAR gamma Endocrinology Blood pressure chemistry Case-Control Studies Female Insulin Resistance Waist Circumference Lipid profile business Body mass index
Zdroj:	Scandinavian Journal of Clinical and Laboratory Investigation. 73:355-360
ISSN:	1502-7686 0036-5513
DOI:	10.3109/00365513.2013.786121
Popis:	Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that regulate transcriptional responses to peroxisome proliferators. There has been limited research concerned with the childhood expression of these receptors. In this study, we aimed to evaluate PPAR-gamma (PPAR-γ) concentrations and their relationship to body mass index (BMI), ratio of waist and hip, blood pressure levels, insulin resistance and lipid profile in obese children and adolescents.Children aged 8-16 years old were included in the study; 44 obese children and 25 healthy children were taken into the study. Blood pressure and waist-hip circumference of obese patients were measured. Following a 12-hour nighttime fasting, venous blood samples were taken, including blood glucose, insulin, lipid profile, liver function tests and PPAR-γ concentrations, and all samples were analyzed at the same time.PPAR-γ concentrations were 0.226 + 0.128 in obese children and 0.547 + 0.546 in the control group. PPAR-γ concentrations were lower in obese children and this difference was statistically significant (p = 0.008). PPAR-γ concentrations of control children were 2.42-fold higher than obese children. There was a negative correlation between PPAR-γ concentrations and waist circumference, and a positive correlation between birth weight and PPAR-γ concentrations in obese children.In our study we found that PPAR-γ concentrations were low in obese children. In adults, treatment modalities aimed at enhancing the activation of PPAR in obesity lead to a decrease in obesity, insulin resistance, dyslipidemia and cardiovascular disease and this gives hope that similar treatment modalities can be used for children.
Databáze:	OpenAIRE
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