Is Keratoconus an Inflammatory Disease? The Implication of Inflammatory Pathways
| Autor: | I-Ping Loh, Trevor Sherwin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Keratoconus
genetic structures Inflammation Disease Proinflammatory cytokine Cornea 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Humans 030203 arthritis & rheumatology Wound Healing business.industry Corneal Topography medicine.disease eye diseases Ophthalmology Tears Immunology 030221 ophthalmology & optometry Cytokines Inflammatory pathways sense organs medicine.symptom business |
| Zdroj: | Ocular immunology and inflammation. 30(1) |
| ISSN: | 1744-5078 |
| Popis: | Keratoconus is considered a non-inflammatory condition. Recently however, increased proinflammatory cytokines have been detected in the tears of keratoconic patients and clinical and immunohistochemical observations reported infiltration of matured dendritic cells and leukocytes. Our laboratory utilized cytokine antibody arrays to elucidate the inflammatory aspects of keratoconus.Protein was extracted from 42 corneal buttons (14 keratoconic and 28 non-keratoconic) and incubated with cytokine antibody arrays scanning 120 cytokines. Mann Whitney U test with aPathways for wound healing, neuroprotection, angiogenesis, and inflammation were activated in keratoconic samples with 23 cytokines showing significant elevation. Fifteen were expressed only in keratoconus with 8 cytokines elevated 1.7-42-fold.This study identified elevated inflammatory pathways covering immune responses in keratoconus. Our results support the evidence for inflammatory pathway activation in keratoconus and a possible redefinition of keratoconus as a chronic inflammatory corneal disease. |
| Databáze: | OpenAIRE |
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