Rat liver model for testing intraoperative echo contrast sonography
| Autor: | H. D. Becker, C. Kuhlo, A. El Mouaaouy, R. Schlief, C. Portas |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Bile duct business.industry Contrast Media Echogenicity Rats Inbred Strains Hepatology Rats Intraoperative Period Liver Neoplasms Experimental medicine.anatomical_structure Single bolus Polysaccharides Internal medicine Contrast echocardiography Rat liver Liver tissue medicine Animals Female Surgery Radiology business Ultrasonography Artery |
| Zdroj: | Surgical Endoscopy. 4:114-117 |
| ISSN: | 1432-2218 0930-2794 |
| Popis: | The present animal experimental study showed that intraoperative hepatic ultrasonography using an echo contrast medium can visualize small hepatomas (with a diameter of between 3 and 15 mm) induced in the rat liver, although they were not recognizable with plain ultrasonography. A homogeneous increase in the echogenicity of the liver tissue was achieved by using an echo contrast medium (Echovist) based on galactose microparticles. Self-made bubble preparations such as those used in echocardiography were far less effective. When the dosage was optimal (0.01-0.003 ml/g liver weight with concentrations of 200 and 300 mg/ml Echovist), homogeneous contrast enhancement of the liver was achieved for at least 10 min after a single bolus injection via all routes of contrast administration (hepatic artery, portal vein, bile duct). As a result, hepatomas appeared as hypodense formations (portal vein and bile duct) or as hyperdense zones (hepatic artery). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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