Novel serotypes 105 and 116 are members of distinct subgroups of Human enterovirus C
| Autor: | Raphael Taty Taty, V. I. Reznik, Gilda Grard, Elena N. Amjaga, Eric M. Leroy, Alexander N. Lukashev, Jan Felix Drexler, Anatoly P. Gmyl, O. E. Trotsenko, Christian Drosten, Valeria O. Kotova |
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| Rok vydání: | 2012 |
| Předmět: |
Serotype
ved/biology.organism_classification_rank.species Enterovirus C Biology Subspecies Coxsackievirus Virus Replication medicine.disease_cause Genome Russia 03 medical and health sciences Phylogenetics Virology Genetic variation Enterovirus Infections medicine Humans Serotyping Phylogeny 030304 developmental biology Genetics 0303 health sciences 030306 microbiology ved/biology Genetic Variation biology.organism_classification Enterovirus C Human Congo RNA Viral Enterovirus Reassortant Viruses |
| Zdroj: | Journal of General Virology. 93:2357-2362 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/vir.0.043216-0 |
| Popis: | The full coding sequences of two novel human enterovirus (HEV)-C serotypes 105 and 116, sampled in the Republic of the Congo in 2010 and in Russia in 2011, were identified in this study. Enterovirus (EV)-105 was closest to EV-104 in the 5′ NTR and to EV-109 in the coding genome region. It had the same unconventional 5′ NTR as EV-104 and EV-109. The non-cytopathogenic EV-116 was phylogenetically close to coxsackievirus (CV)-A1, CV-A19 and CV-A22, which also cannot be propagated in routinely used cell cultures. There were signs of recombination within this subgroup of HEV-C; however, recombination with conventional HEV-C was restricted, implying partial reproductive isolation. As there is also evidence of different permissive replication systems and distinct genetic properties of these subgroups, they may represent subspecies of the HEV-C species or different stages of speciation. |
| Databáze: | OpenAIRE |
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