Subcutaneous immunoglobulin in CIDP and MMN: a short-term nationwide study
| Autor: | Cocito, D., Merola, A., Peci, E., Mazzeo, A., Fazio, R., Francia, A., Valentino, P., Liguori, R., Filosto, M., Siciliano, G., Clerici, A. M., Lelli, S., Marfia, G. A., Antonini, G., Cecconi, I., Nobile-Orazio, E., Lopiano, L., Romagnolo, A., Toscano, A., Gentile, L., Russo, M., Velardo, D., Nistico, R., Donadio, V. A., Schirinzi, E., Bono, G., Clerici, M., Rosso, T., Mataluni, G., Clemenzi, A., Suprani, M. |
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| Přispěvatelé: | D. Cocito, A. Merola, E. Peci, A. Mazzeo, R. Fazio, A. Francia, P. Valentino, R. Liguori, M. Filosto, G. Siciliano, A. M. Clerici, S. Lelli, G. A. Marfia, G. Antonini, I. Cecconi, E. Nobile-Orazio, L. Lopiano, S. C. Ig |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Neurology Time Factors Multifocal motor neuropathy Mismatch negativity Chronic inflammatory demyelinating polyneuropathy 80 and over Prospective Studies Young adult Prospective cohort study Child Chronic Inflammatory Demyelinating Adolescent Adult Aged Aged 80 and over Female Humans Immunoglobulins Immunoglobulins Intravenous Injections Subcutaneous Italy Middle Aged Motor Neuron Disease Polyradiculoneuropathy Chronic Inflammatory Demyelinating Young Adult Inflammatory neuropathy Intravenous immunoglobulin Subcutaneous immunoglobulin chronic inflammatory demyelinating polyradiculoneuropathy Medicine (all) Subcutaneous Neurology (clinical) Settore MED/26 - Neurologia Adolescent Adult Aged Aged 80 and over Child Female Humans Immunoglobulins Immunoglobulins Intravenous Injections Subcutaneous Italy Male Middle Aged Motor Neuron Disease Polyradiculoneuropathy Chronic Inflammatory Demyelinating Prospective Studies Time Factors Young Adult Intravenous medicine.medical_specialty Polyradiculoneuropathy CIDP Injections chronic inflammatory demyelinating polyneuropathy inflammatory neuropathy multifocal motor neuropathy subcutaneous immunoglobulin intravenous immunoglobulin Internal medicine medicine business.industry medicine.disease Surgery IMMUNOGLOBULIN Observational study business |
| Popis: | This multi-center Italian prospective observational study reports the 4 months follow-up data of 87 patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) shifted from intravenous to subcutaneous immunoglobulin treatment. A therapeutic shift from intravenous to subcutaneous immunoglobulin was performed in 87 patients (66 CIDP; 21 MMN) affected by immune-mediated peripheral neuropathies with evidence of a sustained clinical response to intravenous immunoglobulin. Patients were evaluated by means of the Overall Neuropathy Limitation Scale, Medical Research Council Scale and Life Quality Index questionnaire, both at the time of therapeutic shift and after 4 months of subcutaneous immunoglobulin treatment. A sustained clinical efficacy was observed after the switch to subcutaneous immunoglobulin: the Overall Neuropathy Limitation Scale score improved in the group of 66 CIDP patients (P = 0.018), with only one subject reporting a worsening of 1 point, and remained stable in the group of 21 MMN patients (P = 0.841), with one subject reporting a worsening of two points. An improvement in the patient's perception of therapeutic setting was reported in both groups. This large multi-center study confirms the short-term clinical equivalence of subcutaneous versus intravenous immunoglobulin and a possible improvement in the patient's perception of therapeutic setting with the subcutaneous administration. However, further studies are required to extend the results to a longer observational period. |
| Databáze: | OpenAIRE |
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