Little evidence that hepatitis C virus leads to a higher risk of mortality in the absence of cirrhosis and excess alcohol intake: the Swiss Hepatitis C Cohort Study
| Autor: | L, Prasad, V M, Spicher, F, Negro, M, Rickenbach, M, Zwahlen, Gieri, Cathomas |
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| Přispěvatelé: | University of Zurich, Prasad, L |
| Rok vydání: | 2009 |
| Předmět: |
Liver Cirrhosis
Adult Male medicine.medical_specialty Hepatitis C virus Population 610 Medicine & health medicine.disease_cause Risk Assessment Cohort Studies Virology Internal medicine Risk of mortality Humans Medicine education Liver Cirrhosis/*mortality ddc:616 Hepatitis B virus education.field_of_study Hepatitis C Chronic/*complications/*mortality Hepatology business.industry Mortality rate 2725 Infectious Diseases Hepatitis C Hepatitis C Chronic Middle Aged Hepatitis B medicine.disease Alcoholism 10219 Clinic for Gastroenterology and Hepatology Infectious Diseases Standardized mortality ratio Immunology 2406 Virology 2721 Hepatology Female Alcoholism/*complications/*mortality business Switzerland |
| Zdroj: | Journal of Viral Hepatitis, Vol. 16, No 9 (2009) pp. 644-649 |
| ISSN: | 1365-2893 1352-0504 |
| DOI: | 10.1111/j.1365-2893.2009.01113.x |
| Popis: | The objective of this study was to describe the all-cause mortality of participants in the Swiss Hepatitis C Cohort compared to the Swiss general population. Patients with hepatitis C virus (HCV) infection attending secondary and tertiary care centres in Switzerland. One thousand six hundred and forty-five patients with HCV infection were followed up for a mean of over 2 years. We calculated all-cause standardized mortality ratios (SMR) and 95% confidence intervals (CI) using age, sex and calendar year-specific Swiss all-cause mortality rates. Multivariable Poisson regression was used to model the variability of SMR by cirrhotic status, HCV genotype, infection with hepatitis B virus or HIV, injection drug use and alcohol intake. Sixty-one deaths were recorded out of 1645 participants. The crude all-cause SMR was 4.5 (95% CI: 3.5-5.8). Patients co-infected with HIV had a crude SMR of 20 (95% CI: 11.1-36.1). The SMR of 1.1 (95% CI: 0.63-2.03) for patients who were not cirrhotic, not infected with HBV or HIV, did not inject drugs, were not heavy alcohol consumers ( |
| Databáze: | OpenAIRE |
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