Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents
| Autor: | Xingde Li, Leslie Au, Hu Cang, Jingyi Chen, Michael J. Cobb, Zhi-Yuan Li, Benjamin J. Wiley, Fusayo Saeki, Younan Xia, Hui Zhang, Michael B. Kimmey |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Contrast Media
Bioengineering Nanotechnology Imaging phantom Nanocages Optical coherence tomography Cell Line Tumor Neoplasms Materials Testing medicine Humans General Materials Science Particle Size Surface plasmon resonance Absorption (electromagnetic radiation) Immunoassay Bioconjugation Aqueous solution medicine.diagnostic_test Phantoms Imaging Chemistry Scattering Mechanical Engineering General Chemistry Surface Plasmon Resonance Condensed Matter Physics Nanostructures Gold Crystallization Tomography Optical Coherence |
| Zdroj: | Nano Letters. 5:473-477 |
| ISSN: | 1530-6992 1530-6984 |
| DOI: | 10.1021/nl047950t |
| Popis: | Gold nanocages of40 nm in dimension have been synthesized using the galvanic replacement reaction between Ag nanocubes and HAuCl4 in an aqueous solution. By controlling the molar ratio between Ag and HAuCl4, the gold nanocages could be tuned to display surface plasmon resonance peaks around 800 nm, a wavelength commonly used in optical coherence tomography (OCT) imaging. OCT measurements on phantom samples indicate that these gold nanocages have a moderate scattering cross-section of approximately 8.10 x 10(-16) m2 but a very large absorption cross-section of approximately 7.26 x 10(-15) m2, suggesting their potential use as a new class of contrast agents for optical imaging. When bioconjugated with antibodies, the gold nanocages have also been demonstrated for specific targeting of breast cancer cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|