Respective Roles and Interactions of T Lymphocyte and PGE2-Mediated Monocyte Suppressive Activities in Human Newborns and Mothers at the Time of Delivery
| Autor: | Mamas S, C. Griscelli, F. Dray, Alain Fischer, A Durandy |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Rosette Formation T-Lymphocytes medicine.medical_treatment Lymphocyte Cooperation Receptors Antigen B-Cell Cell Communication Biology Lymphocyte Activation T-Lymphocytes Regulatory Dinoprostone Monocytes Immune system Pregnancy Internal medicine Cell Adhesion Leukocytes medicine Humans B cell B-Lymphocytes Fetus Labor Obstetric Immune Sera Prostaglandins E Monocyte Infant Newborn Immunosuppression T lymphocyte Delivery Obstetric In vitro medicine.anatomical_structure Endocrinology Pokeweed Mitogens Cord blood Immunology Female |
| Zdroj: | American Journal of Reproductive Immunology. 2:127-134 |
| ISSN: | 0271-7352 |
| DOI: | 10.1111/j.1600-0897.1982.tb00153.x |
| Popis: | Recently the concept of a poorly functional humoral immune response in the newborn was proposed. Data have been presented indicating that the impaired newborn B cell maturation, as shown in vitro in a pokeweed mitogen-induced B cell maturation system, is due both to an immaturity of lymphocyte subsets and to an increased suppressive T activity. In the present work, we present evidence that there exists a predominance of a naturally occurring T lymphocyte suppressive activity in the cord blood in that the removal of the suppressive activity by irradiation allows a normal maturation of newborn B cells. Such normal maturation of newborn B cells can also be obtained using mixed cultures of adult T cells and newborn B cells. Newborn suppressor T cells belong to both EA gamma (+) and EA gamma (-) fractions, and it is not known whether these two groups do or do not belong to different subsets. The PGE2-dependent monocyte suppressive activity does not play any role in the suppression observed in newborns since newborn monocytes are poorly suppressive and since they produce a smaller amount of PGE2 than adult monocytes. Some observations suggest, on the contrary, that the suppressive T lymphocytes can regulate the levelmore » of the PGE2-dependent monocyte suppressive activity. It should be noticed that similar observations about T lymphocyte and PGE2-dependent monocyte suppressive activities have been made at the same time using mothers' cells. These observations suggest the possibility that such changes in B cell immune regulation may result from an interaction between maternal and fetal lymphoid cells.« less |
| Databáze: | OpenAIRE |
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