Targeting drug memory reconsolidation: a neural analysis
| Autor: | Uršulė Taujanskaitė, Emma N. Cahill, Amy L. Milton |
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| Přispěvatelé: | Cahill, Emma [0000-0003-3054-1708], Milton, Amy [0000-0003-0175-9417], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Drug media_common.quotation_subject Hippocampus Striatum 030226 pharmacology & pharmacy Amygdala 03 medical and health sciences 0302 clinical medicine Treatment targets Memory Drug Discovery medicine Humans Learning Sensory cue media_common Pharmacology Addiction 030104 developmental biology medicine.anatomical_structure nervous system Pharmaceutical Preparations Memory consolidation Psychology Neuroscience |
| Popis: | Addiction can be conceptualised as a disorder of maladaptive learning and memory. Therefore, maladaptive drug memories supporting drug-seeking and relapse behaviours may present novel treatment targets for therapeutic approaches based upon reconsolidation-blockade. It is known that different structures within the limbic corticostriatal system contribute differentially to different types of maladaptive drug memories, including pavlovian associations between environmental cues and contexts with the drug high, and instrumental memories underlying drug-seeking. Here, we review the mechanisms underlying drug memory reconsolidation in the amygdala, striatum, and hippocampus, noting similarities and differences, and opportunities for future research. |
| Databáze: | OpenAIRE |
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