Empowering Electrochemical Biosensing through Nanostructured or Multifunctional Nucleic Acid or Peptide Biomaterials
| Autor: | José Pingarrón, SUSANA CAMPUZANO RUIZ, María Pedrero, Rodrigo Barderas |
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| Přispěvatelé: | Ministerio de Ciencia e Innovación (España), Comunidad de Madrid (España), Instituto de Salud Carlos III |
| Rok vydání: | 2022 |
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| Zdroj: | E-Prints Complutense. Archivo Institucional de la UCM instname |
| Popis: | Electrochemical biosensors continue to evolve at an astonishing pace, con-solidating as competitive tools for determining a wide range of targets and relentlessly strengthening their attributes in terms of sensitivity, selectivity, simplicity, response time, and antifouling ability, making them suitable for getting a foothold in real-world applications. The design and exploitation of nanostructured or multifunctional nucleic acid or peptide biomaterials are playing a determinant role in these achievements. With the aim of high-lighting the potential and opportunities of these biomaterials, this perspec-tive article critically discusses and overviews the electrochemical biosensors reported since 2019 involving nanostructured and multifunctional DNA biomaterials, multifunctional aptamers, modern peptides, and CRISPR/Cas systems. The use of these biomaterials as recognition elements, electrode modifiers (acting as linkers or creating scaffolds with antifouling properties), enzyme substrates, and labeling/carrier agents for signal amplification is discussed through rationally and strategically selected examples, concluding with a personal perspective about the challenges to be faced and future lines of action. The financial support of PID2019-103899RB-I00 (Spanish Ministerio de Ciencia e Innovación) Research Project, the TRANSNANOAVANSENS-CM Program from the Comunidad de Madrid (Grant S2018/NMT-4349), and PI20CIII/00019 Grant from the AES-ISCIII program are gratefully acknowledged. Sí |
| Databáze: | OpenAIRE |
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