The alpha and pi isoenzymes of glutathione S-transferase in human fetal lung: in utero ontogeny compared with differentiation in lung organ culture
| Autor: | Ann Sandison, David Cossar, Robert Hume, Jeanne E. Bell, Richard C. Strange, Mary Jones |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Biophysics
Down-Regulation Organ culture Biochemistry Andrology Tissue culture Embryonic and Fetal Development Organ Culture Techniques Structural Biology Pregnancy medicine Humans Molecular Biology Lung Glutathione Transferase biology Embryogenesis Immunohistochemistry Epithelium Isoenzymes Glutathione S-transferase medicine.anatomical_structure Phenotype In utero Immunology biology.protein Female |
| Zdroj: | Biochimica et biophysica acta. 1037(2) |
| ISSN: | 0006-3002 |
| Popis: | Polyclonal antisera to the alpha and pi isoenzymes of glutathione S-transferase have been used in immunohistochemical studies of developing human lung. In utero expression of the pi set was down-regulated in distal airway cells and the first appearance of pi-negative cells coincided with phenotypic differentiation. In contrast, in the early phase of fetal lung organ culture pi isoenzyme was detected in all differentiated epithelial cells and only as culture progressed did focal negativity develop. The alpha set showed no developmental changes in utero or in organ culture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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