The Public Health Response and Epidemiologic Investigation Related to the Opening of a Bacillus anthracis–Containing Envelope, Capitol Hill, Washington, D.C
| Autor: | Gregory J. Martin, Vincent P. Hsu, Vera A. Semenova, Thomas Handzel, John F. Eisold, Rima F. Khabbaz, Thomas Hales, Cheryl M. Elie, Scott A. Harper, Sandra Romero-Steiner, Anne Schuchat, Rana A. Hajjeh, James A. Hayslett, Ali S. Khan, Conrad P. Quinn, Susan L. Lukacs |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty bioterrorism Population Poison control lcsh:Medicine Mucous membrane of nose Serology lcsh:Infectious and parasitic diseases Anthrax Risk Factors Internal medicine Nasopharynx medicine Humans lcsh:RC109-216 education Workplace education.field_of_study Inhalation Exposure biology business.industry lcsh:R Dispatch Environmental exposure Environmental Exposure Antibiotic Prophylaxis biology.organism_classification United States Surgery Bacillus anthracis Nasal Mucosa Infectious Diseases Nasal Swab Chemoprophylaxis District of Columbia nasal swabs Equipment Contamination epidemiology Public Health Centers for Disease Control and Prevention U.S business postexposure prophylaxis |
| Zdroj: | Emerging Infectious Diseases, Vol 8, Iss 10, Pp 1039-1043 (2002) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | On October 15, 2001, a U.S. Senate staff member opened an envelope containing Bacillus anthracis spores. Chemoprophylaxis was promptly initiated and nasal swabs obtained for all persons in the immediate area. An epidemiologic investigation was conducted to define exposure areas and identify persons who should receive prolonged chemoprophylaxis, based on their exposure risk. Persons immediately exposed to B. anthracis spores were interviewed; records were reviewed to identify additional persons in this area. Persons with positive nasal swabs had repeat swabs and serial serologic evaluation to measure antibodies to B. anthracis protective antigen (anti-PA). A total of 625 persons were identified as requiring prolonged chemoprophylaxis; 28 had positive nasal swabs. Repeat nasal swabs were negative at 7 days; none had developed anti-PA antibodies by 42 days after exposure. Early nasal swab testing is a useful epidemiologic tool to assess risk of exposure to aerosolized B. anthracis. Early, wide chemoprophylaxis may have averted an outbreak of anthrax in this population. |
| Databáze: | OpenAIRE |
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