Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1
| Autor: | Giacomo Benvenuti, Eyal Seidemann, Wilson S. Geisler, Charu Ramakrishnan, Satwant Kumar, Karl Deisseroth, Yuzhi Chen, Spencer T. Chen |
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| Rok vydání: | 2022 |
| Předmět: |
Male
C1V1 genetic structures QH301-705.5 Computer science Science media_common.quotation_subject Perceptual Masking visual perception GCaMP Stimulation Stimulus (physiology) Optogenetics Proof of Concept Study awake behaving monkey General Biochemistry Genetics and Molecular Biology Calcium imaging Visual masking Perception Rhesus macaque medicine Animals Sensory cortex visual cortex neural population coding Biology (General) media_common Neurons General Immunology and Microbiology General Neuroscience General Medicine Macaca mulatta medicine.anatomical_structure Medicine Neuroscience Photic Stimulation Research Article |
| Zdroj: | eLife, Vol 11 (2022) eLife |
| ISSN: | 2050-084X |
| DOI: | 10.7554/elife.68393 |
| Popis: | Can direct stimulation of primate V1 substitute for a visual stimulus and mimic its perceptual effect? To address this question, we developed an optical-genetic toolkit to ‘read’ neural population responses using widefield calcium imaging, while simultaneously using optogenetics to ‘write’ neural responses into V1 of behaving macaques. We focused on the phenomenon of visual masking, where detection of a dim target is significantly reduced by a co-localized medium-brightness mask (Cornsweet and Pinsker, 1965; Whittle and Swanston, 1974). Using our toolkit, we tested whether V1 optogenetic stimulation can recapitulate the perceptual masking effect of a visual mask. We find that, similar to a visual mask, low-power optostimulation can significantly reduce visual detection sensitivity, that a sublinear interaction between visual- and optogenetic-evoked V1 responses could account for this perceptual effect, and that these neural and behavioral effects are spatially selective. Our toolkit and results open the door for further exploration of perceptual substitutions by direct stimulation of sensory cortex. |
| Databáze: | OpenAIRE |
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