Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients
| Autor: | Begoña Fernandez Ruanova, Isabel Oroz, Ane Anton-Ladislao, Yolanda Garcia Fernandez, Alberto F. Cabrera, Marian Gomez-Beldarrain, Urko Aguirre-Larracoechea, Begoña García Zapirain, Juan Carlos Garcia-Monco |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Cingulate gyri Clinical Neurology Cognitive reserve Insula Uncinate fasciculus Audiology 050105 experimental psychology White matter 03 medical and health sciences 0302 clinical medicine Chronic Migraine Fractional anisotropy Medicine 0501 psychology and cognitive sciences Psychiatry Migraine Chronic migraine business.industry 05 social sciences Cognition General Medicine medicine.disease medicine.anatomical_structure Anesthesiology and Pain Medicine Neurology (clinical) business 030217 neurology & neurosurgery Research Article |
| Zdroj: | The Journal of Headache and Pain |
| ISSN: | 1129-2369 |
| DOI: | 10.1186/s10194-016-0593-1 |
| Popis: | Background Structural white matter abnormalities in pain-modulating, regions are present in migraine. Whether they are associated with pain chronification and with cognitive reserve is unclear. Methods Prospective, cohort, six-month study of adult patients with episodic or chronic migraine, and controls. Cognitive reserve, quality of life, impact of pain on daily living, depression and anxiety were assessed. Participants underwent a diffusion-tensor MRI to establish the integrity of white matter tracts of three regions of interest (ROIs) implicated in pain modulation, emotion, cognition and resilience (anterior insula, anterior cingulate gyrus, and uncinate fasciculus). Results Fifty-two individuals were enrolled: 19 episodic migraine patients, 18 chronic migraine patients, and 15 controls. The analysis of the fractional anisotropy in the ROIs showed that those patients with the poorest prognosis (i.e., those with chronic migraine despite therapy at six months -long-term chronic migraneurs) had a significantly lower fractional anisotropy in the right ROIs. Participants with higher cognitive reserve also had greater fractional anisotropy in the right anterior insula and both cingulate gyri. Multivariate analysis showed a significant association between cognitive reserve, migraine frequency, and fractional anisotropy in the right-sided regions of interest. Conclusions Long-term chronic migraine patients show abnormalities in anterior white matter tracts, particularly of the right hemisphere, involved in pain modulation emotion, cognition and resilience. Robustness in these areas is associated with a higher cognitive reserve, which in turn might result in a lower tendency to migraine chronification. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|