The effects of letrozole on ovarian stimulation for fertility preservation in cancer-affected women
| Autor: | Margalida E. Sastre I. Cuadri, Ramon Carreras, Mireia González Comadran, Miguel Ángel Checa Vizcaíno, Anna Robles Corchado, Mario Brassesco |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Oncology medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Oocyte Retrieval Antineoplastic Agents Breast Neoplasms Gonadotropin-Releasing Hormone Breast cancer Ovulation Induction Internal medicine Nitriles medicine Humans Prospective Studies Fertility preservation Aromatase Prospective cohort study Menstrual Cycle Menstrual cycle Retrospective Studies media_common Cryopreservation Gynecology Estradiol biology business.industry Letrozole Ovary Fertility Preservation Obstetrics and Gynecology Cancer Triazoles medicine.disease Reproductive Medicine biology.protein Female Ovulation induction business Developmental Biology medicine.drug |
| Zdroj: | Reproductive BioMedicine Online. 24:606-610 |
| ISSN: | 1472-6483 |
| DOI: | 10.1016/j.rbmo.2012.02.020 |
| Popis: | Survival rates for fertile women with cancer have increased significantly, lending importance to considering the possibility of motherhood after cancer. This study was a retrospective analysis of a prospective database comparing two groups of patients who underwent fertility preservation after being diagnosed with either breast cancer or a non-hormone-dependent cancer between 2009 and 2011. Nineteen oncology patients were included in the study. The objective was to assess the efficacy of ovarian stimulation with aromatase inhibitors versus a standard antagonist protocol. This study sought to quantify oestradiol concentrations in patients receiving letrozole and to determine the length of time between diagnosis of malignancy and onset of fertility preservation. Number of mature oocytes retrieved in the non-hormone-dependent cancer group was comparable to that in the breast cancer group (15.4±8.19 versus 16.3±7.31). Oestradiol concentrations were higher for patients with non-hormone-dependent cancer (1666.4±739.42 pg/ml versus 829±551.11 pg/ml, P=0.006). There were no differences between the groups in the length of time between diagnosis and fertility preservation (17.4±4.93 versus 16.4±1.74 days). Oestradiol concentrations of breast cancer patients on the letrozole protocol remained much lower than those of patients on the antagonist protocol. |
| Databáze: | OpenAIRE |
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