Sarcomatoid Carcinoma Manifesting as Recurrent Rectal Cancer and Mimicking Radiation-Induced Extraskeletal Osteosarcoma: A Case Report
| Autor: | Mi-Jo Lee, Je-Ho Jang, Hyun-Young Han, Hyun-Jin Son, Moon Hyang Park |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty Extraskeletal Osteosarcoma Neoplasms Radiation-Induced Rectum Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine medicine Humans Sarcomatoid carcinoma Aged Osteosarcoma Abdominoperineal resection business.industry Rectal Neoplasms Carcinoma medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Adenocarcinoma 030211 gastroenterology & hepatology Surgery Anatomy Differential diagnosis Neoplasm Recurrence Local business Epithelioid cell Chemoradiotherapy |
| Zdroj: | International journal of surgical pathology. 25(8) |
| ISSN: | 1940-2465 |
| Popis: | Here, we report an unusual case of sarcomatoid carcinoma mimicking extraskeletal osteosarcoma that manifested as recurrent rectal cancer. Five years earlier, a 76-year-old male patient had undergone neoadjuvant chemoradiotherapy followed by a laparoscopic low anterior resection due to adenocarcinoma of the rectum. He was admitted because of pain in the anus and left hip. He underwent abdominal computed tomography that revealed a newly developed left perirectal mass with gluteus maximus invasion measuring up to 8 cm, and therefore, an abdominoperineal resection was performed. Histologically, the tumor revealed sheets of spindled or epithelioid cells, an absence of gland formation, mucicarmine and periodic acid–Schiff stain negativity, and prominent intercellular deposits of osteoid-like calcified tissue. Tumor cells were diffusely immunoreactive for vimentin and cytokeratins. Ultrastructural examination demonstrated microvilli on the surface or within intercellular spaces. In this report, we also discuss the possible pathogenesis as well as the differential diagnosis. |
| Databáze: | OpenAIRE |
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