Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality
| Autor: | Daniel C. H. Schröder, Martin W. Dünser, Christian Torgersen, Christian A. Schmittinger, Günter Luckner, Hanno Ulmer, Christopher Rex |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Vasopressin endocrine system Hydrocortisone Anti-Inflammatory Agents macromolecular substances Critical Care and Intensive Care Medicine Gastroenterology Hemostatics Cohort Studies Sepsis Internal medicine Outcome Assessment Health Care medicine Humans Statistics & numerical data Aged Proportional Hazards Models Retrospective Studies business.industry Septic shock urogenital system Extracorporeal circulation Middle Aged Eye infection medicine.disease Shock Septic Surgery Arginine Vasopressin Intensive Care Units nervous system Austria Shock (circulatory) Concomitant Drug Therapy Combination Female medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Torgersen, Christian; Luckner, Günter; Schröder, Daniel C H; Schmittinger, Christian A; Rex, Christopher; Ulmer, Hanno; Dünser, Martin W (2011). Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality. Intensive care medicine, 37(9), pp. 1432-7. Berlin: Springer-Verlag 10.1007/s00134-011-2312-3 |
| DOI: | 10.7892/boris.6926 |
| Popis: | Purpose: To evaluate the association between concomitant arginine-vasopressin (AVP)/hydrocortisone therapy and mortality in severe septic shock patients. Methods: This retrospective study included severe septic shock patients treated with supplementary AVP. To test the association between concomitant AVP/hydrocortisone use and mortality, a multivariate regression and Cox model (adjusted for admission year, initial AVP dosage and the Sepsis-related Organ Failure Assessment score before AVP) as well as a propensity score-based analysis were used. In both models, intensive care unit (ICU) and 28-day mortality served as outcome variables. Results: One hundred fifty-nine patients were included. Hydrocortisone was administered to 76 (47.8%) at a median daily dosage of 300 (200-300)mg. In the multivariate logistic regression model, concomitant use of AVP and hydrocortisone was associated with a trend towards lower ICU (OR, 0.51; CI 95%, 0.24-1.08; p=0.08) and 28-day (HR, 0.69; CI 95%, 0.43-1.08; p=0.11) mortality. The probability of survival at day 28, as predicted by the regression model, was significantly higher in patients treated with concomitant AVP and hydrocortisone compared to those receiving AVP without hydrocortisone (p=0.001). In a propensity score-based analysis, ICU (45 vs. 65%; OR, 0.69; CI 95% 0.38-1.26; p=0.23) and 28-day mortality (35.5 vs. 55%; OR, 0.59; CI 95%, 0.27-1.29; p=0.18) was not different between patients treated with (n=40) or without concomitant hydrocortisone (n=40). Conclusion: Concomitant AVP and hydrocortisone therapy may be associated with a survival benefit in septic shock. An adequately powered, randomised controlled trial appears warranted to confirm these preliminary, hypothesis-generating results |
| Databáze: | OpenAIRE |
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