Influence of Computer-Aided Detection False-Positives on Reader Performance and Diagnostic Confidence for CT Colonography
| Autor: | James Lenton, Stuart A. Taylor, Anthony Goldstone, Peter Wylie, Paul Bassett, Steve Halligan, L Honeyfield, John Brittenden, Hannah Lambie, Damian Tolan, David Burling |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Virtual colonoscopy Attitude of Health Personnel Colonic Polyps CAD Sensitivity and Specificity Pattern Recognition Automated Sphericity Artificial Intelligence False positive paradox Humans Medicine False Positive Reactions Radiology Nuclear Medicine and imaging Aged Observer Variation Receiver operating characteristic medicine.diagnostic_test business.industry Computer aid Reproducibility of Results Mean age General Medicine Computer aided detection Radiographic Image Enhancement Radiographic Image Interpretation Computer-Assisted Female Radiology business Nuclear medicine Colonography Computed Tomographic Algorithms |
| Zdroj: | American Journal of Roentgenology. 192:1682-1689 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.08.1625 |
| Popis: | The objective of our study was to investigate whether an increasing number of computer-aided detection (CAD) false-positives decreases reader sensitivity, specificity, and confidence for nonexpert readers of CT colonography (CTC).Fifty CTC data sets (29 men; mean age, 65 years), 25 of which contained 35 polypsor = 5 mm, were selected in which CAD had 100% polyp sensitivity at two sphericity settings (0 and 75) but differed in the number of false-positives. The data sets were read by five readers twice: once at each sphericity setting. Sensitivity, specificity, report time, and confidence before and after second-read CAD were compared using the paired exact and Student's t test, respectively. Receiver operating characteristic (ROC) curves were generated using reader confidence (1-100) in correct case classification (normal or abnormal).CAD generated a mean of 42 (range, 3-118) and 15 (range, 1-36) false-positives at a sphericity of 0 and 75, respectively. CAD at both settings increased per-patient sensitivity from 82% to 87% (p = 0.03) and per-polyp sensitivity by 8% and 10% for a sphericity of 0 and 75, respectively (p0.001). Specificity decreased from 84% to 79% (sphericity 0 and 75, p = 0.03 and 0.07). There was no difference in sensitivity, specificity, or reader confidence between sphericity settings (p = 1.0, 1.0, 0.11, respectively). The area under the ROC curve was 0.78 (95% CI, 0.70-0.86) and 0.77 (0.68-0.85) for a sphericity of 0 and 75, respectively. CAD added a median of 4.4 minutes (interquartile range [IQR], 2.7-6.5 minutes) and 2.2 minutes (IQR, 1.2-4.0 minutes) for a sphericity of 0 and 75, respectively (p0.001). CONCLUSION. CAD has the potential to increase the sensitivity of readers inexperienced with CTC, although specificity may be reduced. An increased number of CAD-generated false-positives does not negate any beneficial effect but does reduce efficiency. |
| Databáze: | OpenAIRE |
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