A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

Autor:	Yanming Wang, Bradley T. Hyman, Manik L. Debnath, Daniel P. Holt, Brian J. Bacskai, William E. Klunk, Matthew P. Frosch, Guo Feng Huang, Stephen T. Kajdasz, Chester A. Mathis, Megan E. McLellan
Rok vydání:	2002
Předmět:	Genetically modified mouse Amyloid Chemical Phenomena Clinical Biochemistry Pharmaceutical Science Mice Transgenic Plaque Amyloid Binding Competitive Biochemistry Mice Structure-Activity Relationship chemistry.chemical_compound Nuclear magnetic resonance Alzheimer Disease In vivo mental disorders Drug Discovery medicine Animals Benzothiazoles Molecular Biology Microscopy medicine.diagnostic_test Chemistry Physical Organic Chemistry Brain medicine.disease Imaging agent Thiazoles Benzothiazole chemistry Positron emission tomography Molecular Medicine Thioflavin Radiopharmaceuticals Alzheimer's disease Tomography Emission-Computed
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 12:295-298
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)00734-x
Popis:	The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe179b782c5465f7e6c92d409f66bdc https://doi.org/10.1016/s0960-894x(01)00734-x Zobrazit plný text záznamu Full Text from ScienceDirect