Prodrug approaches to enhancement of physicochemical properties of drugs IX: acetaminophen prodrug
| Autor: | Donald G. Perrier, Anwar A. Hussain, Prakash Kulkarni |
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| Rok vydání: | 1978 |
| Předmět: |
Male
Chemistry organic chemicals Hydrolysis digestive oral and skin physiology Pharmaceutical Science Biological Availability Prodrug Pharmacology Hydrogen-Ion Concentration digestive system Combinatorial chemistry digestive system diseases Acetaminophen Bioavailability stomatognathic diseases Kinetics Dogs medicine Animals Neutral ph medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 67(4) |
| ISSN: | 0022-3549 |
| Popis: | The synthesis, hydrolysis rate, and bioavailability of 1-(p-acetaminophenoxy)-1-ethoxyethane, an acetaminophen prodrug, are described. The prodrug is less soluble than acetaminophen and stable at neutral pH. However, in an acidic environment, the compound cleaves rapidly, generating acetaminophen. When both the prodrug and acetaminophen were administered to dogs in equivalent amounts, the blood acetaminophen levels were comparable. |
| Databáze: | OpenAIRE |
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