Penetration of moxifloxacin into sternal bone of patients undergoing routine cardiopulmonary bypass surgery
| Autor: | Georgios Theodoridis, A. Tsona, Georgia Lazaraki, Simeon Metallidis, Pavlos Nikolaidis, Efi Alexiadou, John Nikolaidis, Nikolaos Charokopos, Eleni Koumentaki |
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| Rok vydání: | 2006 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Sternum Moxifloxacin law.invention Surgical anastomosis Cardiopulmonary bypass surgery Anti-Infective Agents law Cardiopulmonary bypass Medicine Humans Pharmacology (medical) Infusions Intravenous Chromatography High Pressure Liquid Antibacterial agent Aged Aza Compounds Cardiopulmonary Bypass business.industry Manubrium Osteomyelitis General Medicine Penetration (firestop) Middle Aged medicine.disease Surgery Anti-Bacterial Agents Infectious Diseases Anesthesia Quinolines Female Osteitis business medicine.drug Fluoroquinolones |
| Zdroj: | International journal of antimicrobial agents. 28(5) |
| ISSN: | 0924-8579 |
| Popis: | This study investigated plasma and bone concentrations of moxifloxacin following a single intravenous dose of 400mg to consider its potential role in the treatment of osteomyelitis. Eight patients who underwent routine cardiopulmonary bypass surgery were enrolled in the study. Plasma and bone samples were collected 2h and 5h after the end of infusion. High performance liquid chromatography was used for the determination of moxifloxacin concentrations. Mean plasma concentrations were 3.36 microg/mL and 2.93 microg/mL at 2h and 5h after the end of infusion. The concentrations in the body and manubrium of the sternal bone were 1.65 microg/g and 1.64 microg/g at 2h and 1.4 microg/g and 1.45 microg/g at 5h, respectively. Moxifloxacin showed good penetration into bone and could be considered for the treatment of osteomyelitis. |
| Databáze: | OpenAIRE |
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