Microfluidic Spectrophotometer for Neurotransmitter Detection Based on Gold Nanoparticles: Preliminary Results
| Autor: | Elodie Boisselier, Shimwe Dominique Niyonambaza, Amine Miled, Mounir Boukadoum |
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| Rok vydání: | 2018 |
| Předmět: |
Neurotransmitter Agents
Materials science Absorption spectroscopy business.industry Microfluidics Color Metal Nanoparticles Nanoparticle 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Laser 01 natural sciences 0104 chemical sciences Vertical-cavity surface-emitting laser law.invention Absorbance Colloidal gold law Optoelectronics Gold 0210 nano-technology business Visible spectrum Light-emitting diode |
| Zdroj: | EMBC |
| DOI: | 10.1109/embc.2018.8513287 |
| Popis: | A microfluidic-based spectrophotometer for neurotransmitters sensing is presented in this paper. In addition, a neurotransmitter photo-fingerprint is analyzed to evaluate the feasibility of selective neurotransmitter detection using optical techniques. The aim of this work is to detect major neurotransmitters (NTs) using a compact, portable and cost effective optical system for selective and real time NT concentration monitoring. Micro-spectroscopic detection of NTs is challenging because most of them are transparent to visible light. Nevertheless, they interfere with the absorption spectrum of gold nanoparticles (Au-NP), which exhibit maximum absorbance in the range of 520 nm. We observed an Au-NP maximum absorbance shift of up to 4nm in presence of NTs. Based on this shift, it is possible to detect NTs using visible ligh by using vertical-cavity surface-emitting laser (VCSEL) as light sources and an integrated system-on-chip (SoC) spectrophotometer. |
| Databáze: | OpenAIRE |
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