Apolipoprotein(a) in insulin-dependent diabetic patients with and without diabetic nephropathy
| Autor: | M. A. Gall, P. Andersen, Eva Hommel, Flemming S Nielsen, Peter Rossing, H.-H. Parving, A. I. Voldsgaard, J. Dyerberg |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Diabetes duration medicine.medical_specialty Apolipoprotein B Clinical Biochemistry Blood Pressure Diabetic nephropathy Internal medicine Albuminuria Humans Medicine Diabetic Nephropathies Risk factor biology business.industry Cholesterol HDL General Medicine Middle Aged medicine.disease Apolipoproteins Diabetes Mellitus Type 1 Endocrinology Atherogenic lipoprotein biology.protein Female Microalbuminuria Insulin dependent business Body mass index Lipoprotein(a) |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 52:513-521 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365519209090129 |
| Popis: | Insulin-dependent diabetic patients with diabetic nephropathy have a highly increased morbidity and mortality from cardiovascular diseases. To determine whether altered levels of apolipoprotein(a) (apo(a)), the glycoprotein of the potentially atherogenic lipoprotein(a) (Lp(a)), contribute to the increased risk of ischaemic heart disease, apo(a) was determined in 50 insulin-dependent diabetic patients with diabetic nephropathy (group 1), in 50 insulin-dependent diabetic patients with microalbuminuria (group 2), in 50 insulin-dependent diabetic patients with normoalbuminuria (group 3), and in 50 healthy subjects (group 4). The groups were matched with regard to sex, age and body mass index. The diabetic groups were also matched with regard to diabetes duration. The level of apo(a) was approximately the same in the four groups, being: 122 (x/ divided by 4.2) U l-1, 63 (x/ divided by 4.4) U l-1, 128 (x/ divided by 3.5) U l-1 and 126 (x/ divided by 3.7) U l-1 (geometric mean (x/ divided by antilog SD)) in group 1, 2, 3 and 4, respectively. 1 U l-1 apo(a) approximates 0.7 mg l-1 Lp(a).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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