Plasma catecholamine concentrations in essential hyperhidrosis and effects of thoracoscopic D2-D3 sympathicolysis
| Autor: | E. Gerlo, Walter Vincken, Claude Sevens, Marc Noppen |
|---|---|
| Přispěvatelé: | Internal Medicine Specializations |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Epinephrine medicine.medical_treatment Clinical Biochemistry Biochemistry Norepinephrine Sympathicolysis chemistry.chemical_compound Internal medicine medicine Humans Hyperhidrosis Sympathectomy Neurotransmitter Ganglia Sympathetic business.industry Thoracoscopy PALMAR HYPERHIDROSIS General Medicine Plasma levels Middle Aged Endocrinology chemistry Catecholamine Female medicine.symptom business Acetylcholine medicine.drug |
| Zdroj: | Vrije Universiteit Brussel |
| ISSN: | 0014-2972 |
| DOI: | 10.1046/j.1365-2362.1997.870647.x |
| Popis: | Essential hyperhidrosis (EH) is caused by a poorly understood overactivity of the sympathetic fibres passing through the upper dorsal sympathetic ganglia D2 and D3. These ganglia are also in the pathway of the sympathetic innervation of the heart and lungs. Therefore, although the predominant sympathetic neurotransmitter at the eccrine sweat glands is acetylcholine, the plasma concentration of noradrenaline (NA) (which is the main sympathetic neurotransmitter at the end organs including the heart and the lungs) may be elevated. Furthermore, as there are some indications for generalized sympathetic overactivity in EH, the plasma concentration of adrenaline (A) may also be elevated. Plasma levels of NA and A were therefore determined in 13 EH patients before and after thoracoscopic D2-D3 sympathicolysis (TS). Preoperative NA and A plasma levels were all within the normal limits used in our laboratory. After TS, mean NA plasma levels are significantly decreased, whereas mean A are unchanged. We conclude that sympathetic overactivity in EH is limited to the upper dorsal sympathetic ganglia and that some of the cardiovascular and pulmonary effects that are observed after TS may be associated with the decrease in NA. |
| Databáze: | OpenAIRE |
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