Mild encephalopathy with reversible lesions in the splenium of corpus callosum and bilateral cerebral deep white matter in identical twins
| Autor: | Rikken Maruyama, Shigeru Makino, Shin-ichiro Tanaka, Jun Shinozuka, Junko Tahara, Shinsaku Imashuku, Hitoshi Awaguni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Corpus callosum
Encephalopathy Splenium lcsh:Medicine Case Report Pediatrics 030218 nuclear medicine & medical imaging White matter Lesion 03 medical and health sciences Dysarthria 0302 clinical medicine medicine Identical twins First episode medicine.diagnostic_test business.industry lcsh:R lcsh:RJ1-570 Splenial lesion Magnetic resonance imaging lcsh:Pediatrics medicine.disease medicine.anatomical_structure Anesthesia medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Pediatric Reports, Vol 8, Iss 3 (2016) Pediatric Reports Volume 8 Issue 3 |
| ISSN: | 2036-7503 |
| Popis: | Identical twin brothers developed mild encephalopathy at the age of 7.0 and 9.7 years (Patient 1) and 10.7 years (Patient 2). Patient 1 had influenza A at the time of his second episode, but triggering agents were not evident at the first episode. The triggering agents in Patient 2 were unclear. The neurological features of both patients included transient facial numbness, left arm paresis, dysarthria, and gait disturbance. Diffusion-weighted images from magnetic resonance imaging showed high signal levels at the splenium of corpus callosum and in the bilateral cerebral deep white matter. These results are characteristic of mild encephalitis/encephalopathy with a reversible isolated splenium of corpus callosum lesion. All three episodes were treated with a methylprednisolone pulse. Acyclovir was also administered to Patient 2 and to Patient 1 during his first episode. Patient 1 received an anti-influenza agent and intravenous immunoglobulin during his second episode. Both patients recovered completely without sequelae. Genetic factors, which may predispose identical twins to develop encephalopathy, are discussed. |
| Databáze: | OpenAIRE |
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