Inhibitory effects of mycobacterial cell wall lipids on bovine lung surfactant extract: An in vitro study at the air–aqueous interface
| Autor: | Rangan Banerjee, G. Chimote |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Serum
Bacterial cell structure Mycolic acid Alveolar cells Mycobacterium tuberculosis Pulmonary Tuberculosis Colloid and Surface Chemistry Mycolic Acid Pulmonary surfactant Mechanisms medicine Tuberculosis Lung Surfactant Dysfunction chemistry.chemical_classification Cord factor biology Chemistry Albumin Dipalmitoylphosphatidylcholine Monolayers respiratory system biology.organism_classification In vitro Cord Factor medicine.anatomical_structure Biochemistry Dysfunction Adsorption Pulmonary Surfactant Bacteria |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 338:7-14 |
| ISSN: | 0927-7757 |
| DOI: | 10.1016/j.colsurfa.2008.12.002 |
| Popis: | Lung surfactant is a lipoprotein Mixture synthesized by the type [I alveolar cells in the lungs and lines the air-aqueous interface. It is essential for stabilizing the pulmonary alveoli. Deficiency or dysfunction of the surfactant due to chemicals or toxins results in alveolar collapse and if untreated leads to respiratory distress. In pulmonary tuberculosis, Mycobacterium tuberculosis bacteria reside in the alveoli, in close physical proximity with the alveolar surfactant. The surface active mycobacterial cell wall lipids may easily detach from bacterial cell wall and interact with surfactant components altering their surface activity. In this study, effects of mycolic acid and cord factor (the abundant surface lipids of mycobacterial cell wall) oil the surface activity of modified bovine surfactant extract (Survanta (TM)) were characterized in vitro using the Wilhelmy surface balance at physiological temperature (37 degrees C) and pH 7.4. Inhibitory effects of mycobacterial cell wall lipids oil the terminal airway surfactant were evaluated using a capillary surfactometer. Addition of graded amounts of mycolic acid and cord factor significantly increased the minimum Surface tension Of survanta (TM) monolayer from |
| Databáze: | OpenAIRE |
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