The effect of bovine insulin on [14C]glucose and [3H]leucine incorporation in fed and fasted rainbow trout (Salmo gairdneri)
| Autor: | Daniel P. Selivonchick, Russell O. Sinnhuber, Richard F. Ablett |
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| Rok vydání: | 1981 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Trout medicine.medical_treatment Stimulation Oxidative phosphorylation Biology Hypoglycemia chemistry.chemical_compound Endocrinology Leucine Internal medicine medicine Animals Insulin Glycogen Muscles Skeletal muscle Fasting Lipid Metabolism medicine.disease Glucose medicine.anatomical_structure Liver chemistry Basal metabolic rate Animal Science and Zoology Salmonidae |
| Zdroj: | General and Comparative Endocrinology. 44:418-427 |
| ISSN: | 0016-6480 |
| DOI: | 10.1016/0016-6480(81)90328-2 |
| Popis: | The effect of bovine insulin on tissue incorporation of [14C]glucose and [3H]leucine was investigated in fed and fasted rainbow trout reared on a control and high-protein diet. Insulin produced marked hypoglycemia and mobilization of liver glycogen in all treatments. Although insulin gave no evidence of glycogenic stimulation it did appear to promote oxidative clearance of [14C]glucose. Compared to [14C]glucose much greater tissue incorporation of [3H]leucine was observed in fasted fish; insulin stimulated the incorporation of [3H]leucine into skeletal muscle protein. In plasma, liver, and skeletal muscle of all treatments, the summed specific activities of [3H]leucine was considerably greater than that of the summed values of [14C]glucose following insulin administration. Four weeks of fasting apparently lowered basal metabolism but no changes were observed in plasma glucose and glycogen stores. There was some evidence of gluconeogenic activity in the high protein-fasted fish and the data indicated in all fasted treatments a stimulation of [14C]glucose and [3H]leucine metabolism following insulin administration. |
| Databáze: | OpenAIRE |
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