Ferrous ion-stimulated alkane expiration in rats treated with carbon tetrachloride
| Autor: | H. Kappus, H. Muliawan |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Alkane chemistry.chemical_classification Lipid Peroxides Iron Inorganic chemistry chemistry.chemical_element Rats Inbred Strains Toxicology Oxygen Rats Ferrous Pentane Lipid peroxidation chemistry.chemical_compound chemistry Propane Alkanes Carbon tetrachloride Animals Limiting oxygen concentration Ferrous Compounds Carbon Tetrachloride Nuclear chemistry |
| Zdroj: | Toxicology. 28:29-36 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(83)90103-8 |
| Popis: | Rats which were treated intraperitoneally (i.p.) with FeCl 2 · 4H 2 O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl 2 of stored ethane from the body was excluded. Propane expiration was also stimulated by FeCl 2 treatment, whereas n -pentane expiration could not be detected. Rats which were treated i.p. with 500 mg CCl 4 /kg expired ethane, propane, and n -pentane, the amounts being higher in the presence of 20% than in the presence of 100% oxygen. The treatment of rats with FeCl 2 30 min after giving CCl 4 resulted in a 2–5-fold increase in ethane, propane and n -pentane expiration, the total amounts depending on the oxygen concentration in the respired air (higher under 20% and lower under 100% oxygen). This increase was due to a minor extent to FeCl 2 -inititated alkane formation. Therefore, we suggest that in vivo Fe 2+ , besides its ability to initiate lipid peroxidation, influences the CCl 4 -induced lipid peroxidation process. The possible relevance for CCl 4 toxicity is discussed. |
| Databáze: | OpenAIRE |
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