Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia

Autor: Henry Baffoe-Bonnie, Abdullah M. Assiri, Ra’ed Hijazi, Hanan H. Balkhy, Abdulaziz Bin Saeed, Aiman El-Saed, Sameera M. Al Johani, Majid Alshamrani, Thamer H. Alenazi, Hail M. Al-Abdely, Yaseen M. Arabi
Rok vydání: 2016
Předmět:
0301 basic medicine
Microbiology (medical)
Adult
Male
Pediatrics
medicine.medical_specialty
Infectious Disease Transmission
Patient-to-Professional
Epidemiology
Middle East respiratory syndrome coronavirus
Health Personnel
030106 microbiology
Saudi Arabia
Comorbidity
medicine.disease_cause
law.invention
Disease Outbreaks
Tertiary Care Centers
03 medical and health sciences
0302 clinical medicine
law
medicine
Infection control
Humans
030212 general & internal medicine
Prospective Studies
Aged
Nasal Septum
Aged
80 and over
Cross Infection
Infection Control
business.industry
Reverse Transcriptase Polymerase Chain Reaction
Outbreak
Emergency department
Original Articles
Middle Aged
medicine.disease
Intensive care unit
Respiration
Artificial
Infectious Diseases
Middle East Respiratory Syndrome Coronavirus
Middle East respiratory syndrome
Female
business
Coronavirus Infections
Contact tracing
Zdroj: Infection Control and Hospital Epidemiology
ISSN: 1559-6834
0899-823X
Popis: BACKGROUNDSince the first isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in 2012, sporadic cases, clusters, and sometimes large outbreaks have been reported.OBJECTIVETo describe the recent (2015) MERS-CoV outbreak at a large tertiary care hospital in Riyadh, Saudi Arabia.METHODSWe conducted an epidemiologic outbreak investigation, including case finding and contact tracing and screening. MERS-CoV cases were categorized as suspected, probable, and confirmed. A confirmed case was defined as positive reverse transcription polymerase chain reaction test for MERS-CoV.RESULTSOf the 130 suspected cases, 81 (62%) were confirmed and 49 (38%) were probable. These included 87 patients (67%) and 43 healthcare workers (33%). Older age (mean [SD], 64.4 [18.3] vs 40.1 [11.3] years, P<.001), symptoms (97% vs 58%, P<.001), and comorbidity (99% vs 42%, P<.001) were more common in patients than healthcare workers. Almost all patients (97%) were hospitalized whereas most healthcare workers (72%) were home isolated. Among 96 hospitalized cases, 63 (66%) required intensive care unit management and 60 (63%) required mechanical ventilation. Among all 130 cases, 51 (39%) died; all were patients (51 [59%]) with no deaths among healthcare workers. More than half (54%) of infections were believed to be caught at the emergency department. Strict infection control measures, including isolation and closure of the emergency department, were implemented to interrupt the chain of transmission and end the outbreak.CONCLUSIONMERS-CoV remains a major healthcare threat. Early recognition of cases and rapid implementation of infection control measures are necessary.Infect Control Hosp Epidemiol 2016;1–9
Databáze: OpenAIRE
Externí odkaz: