The brachymorph mouse and the developmental-genetic basis for canalization and morphological integration
| Autor: | H. David Sheets, Miriam Leah Zelditch, Benedikt Hallgrímsson, Alice F. Ford-Hutchinson, Frank R. Jirik, Jevon J. Y. Brown |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Context (language use) Biology Chondrocranium Gene Expression Regulation Enzymologic Mice Sulfation Multienzyme Complexes Genetic variation Morphogenesis Animals Gene Ecology Evolution Behavior and Systematics Genetics Skull Wild type Genetic Variation Phenotype Mice Mutant Strains Sulfate Adenylyltransferase Mice Inbred C57BL Anatomy Comparative Mutation (genetic algorithm) Mutation Female Developmental Biology |
| Zdroj: | Evolutiondevelopment. 8(1) |
| ISSN: | 1520-541X |
| Popis: | SUMMARY Although it is well known that many mutations influence phenotypic variability as well as the mean, the underlying mechanisms for variability effects are very poorly understood. The brachymorph (bm) phenotype results from an autosomal recessive mutation in the phosphoadenosine-phosphosulfate synthetase 2 gene (Papps2). A major cranial manifestation is a dramatic reduction in the growth of the chondrocranium which results from undersulfation of glycosaminoglycans (GAGs) in the cartilage matrix. We found that this reduction in the growth of the chondrocranium is associated with an altered pattern of craniofacial shape variation, a significant increase in phenotypic variance and a dramatic increase in morphological integration for craniofacial shape. Both effects are largest in the basicranium. The altered variation pattern indicates that the mutation produces developmental influences on shape that are not present in the wildtype. As the mutation dramatically reduces sulfation of GAGs, we infer that this influence is variation among individuals in the degree of sulfation, or variable expressivity of the mutation. This variation may be because of genetic variation at other loci that influence sulfation, environmental effects, or intrinsic effects. We infer that chondrocranial development exhibits greater sensitivity to variation in the sulfation of chondroitin sulfate when the degree of sulfation is low. At normal levels, sulfation probably contributes minimally to phenotypic variation. This case illustrates canalization in a particular developmentalgenetic context. |
| Databáze: | OpenAIRE |
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