Value of Shear Wave Elastography for the Differentiation of Benign and Malignant Microcalcifications of the Breast
| Autor: | Matthew Seidler, Fanny Pinel-Giroux, Benoit Gallix, Raluca Antonescu, Atilla Omeroglu, Caroline Reinhold, Mélanie Thériault, Silma Solorzano, Ellen Kao, Ann Aldis, Foucauld Chamming's, Benoît Mesurolle |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Biopsy Breast Neoplasms Malignancy Sensitivity and Specificity 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Aged Aged 80 and over Shear wave elastography Receiver operating characteristic medicine.diagnostic_test business.industry Ultrasound Calcinosis General Medicine Ductal carcinoma Middle Aged medicine.disease 030220 oncology & carcinogenesis Mann–Whitney U test Elasticity Imaging Techniques Female Radiology Elastography Ultrasonography Mammary business Mammography |
| Zdroj: | AJR. American journal of roentgenology. 213(2) |
| ISSN: | 1546-3141 |
| Popis: | OBJECTIVE. The objective of our study was to evaluate whether shear wave elastography (SWE) can differentiate benign from malignant microcalcifications of the breast when detected on ultrasound (US). SUBJECTS AND METHODS. Between February 9, and June 23, 2016, 74 patients with mammographically detected suspicious microcalcifications underwent breast US. When microcalcifications were identified on US, stiffness was assessed using SWE. Biopsy was subsequently performed under US guidance using a 10-gauge vacuum-assisted needle. Qualitative and quantitative elastography results were compared between benign and malignant calcifications as well as between pure ductal carcinoma in situ and lesions with invasive components using the Mann-Whitney U test. ROC curves were created to assess the performance of SWE in detecting malignancy and invasive components. RESULTS. Twenty-nine groups of microcalcifications in 29 patients were identified on US. At pathology, 16 groups were benign and 13 were malignant. Stiffness of malignant calcifications was significantly higher than that of the benign ones (p = 0.0004). The AUC, sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of SWE for the diagnosis of malignancy were 0.89, 69%, 100%, 80%, 100%, and 86%, respectively, and for detection of an invasive component were 0.93, 75%, 100%, 75%, 100%, and 85%. CONCLUSION. SWE has the potential to differentiate benign from malignant micro-calcifications of the breast when detected on US with high specificity. |
| Databáze: | OpenAIRE |
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