Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein
Autor: | Yuliu Chen, Yan Wu, Shaoying Chen, Qingping Zhan, Dingzhou Wu, Chan Yang, Xiaoxue He, Mengjie Qiu, Nannan Zhang, Zhaofeng Li, Yunhua Guo, Minjun Wen, Lu Lu, Cuiqing Ma, Jiayin Guo, Wei Xu, Xiaojuan Li, Lin Li, Shibo Jiang, Xiaoyan Pan, Shuwen Liu, Suiyi Tan |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Journal of Virology. 96 |
ISSN: | 1098-5514 0022-538X |
Popis: | The global spread of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the continuously emerging new variants underscore an urgent need for effective therapeutics for the treatment of coronavirus disease 2019 (COVID-19). Here, we screened several FDA-approved amphiphilic drugs and determined that sertraline (SRT) exhibits potent antiviral activity against infection of SARS-CoV-2 pseudovirus (PsV) and authentic virus |
Databáze: | OpenAIRE |
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