Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein

Autor:	Yuliu Chen, Yan Wu, Shaoying Chen, Qingping Zhan, Dingzhou Wu, Chan Yang, Xiaoxue He, Mengjie Qiu, Nannan Zhang, Zhaofeng Li, Yunhua Guo, Minjun Wen, Lu Lu, Cuiqing Ma, Jiayin Guo, Wei Xu, Xiaojuan Li, Lin Li, Shibo Jiang, Xiaoyan Pan, Shuwen Liu, Suiyi Tan
Rok vydání:	2022
Předmět:	Mice SARS-CoV-2 Sertraline Virology Insect Science Spike Glycoprotein Coronavirus Immunology Animals Humans COVID-19 Virus Internalization Antiviral Agents Microbiology
Zdroj:	Journal of Virology. 96
ISSN:	1098-5514 0022-538X
Popis:	The global spread of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the continuously emerging new variants underscore an urgent need for effective therapeutics for the treatment of coronavirus disease 2019 (COVID-19). Here, we screened several FDA-approved amphiphilic drugs and determined that sertraline (SRT) exhibits potent antiviral activity against infection of SARS-CoV-2 pseudovirus (PsV) and authentic virus
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd5b000cf75b714f9b78cd76ebdcd18 https://doi.org/10.1128/jvi.01245-22 Zobrazit plný text záznamu