Effects of different plasma target concentrations of remifentanil on the MACBAR of sevoflurane in children with laparoscopic surgery

Autor:	Dan Wang, Ping-Ping Jiang, Yang Xiaolin, Juan Xu, Yan-Xia Guo, Guo-Yuan Zhang
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Laparoscopic surgery Insufflation Minimum alveolar concentration business.industry medicine.medical_treatment Significant difference Remifentanil Pneumoperitoneum stimulus Sevoflurane Anesthesiology and Pain Medicine Epinephrine Anesthesiology Anesthesia medicine RD78.3-87.3 business Children Minimum alveolar concentration (MAC) medicine.drug Carbon dioxide pneumoperitoneum
Zdroj:	BMC Anesthesiology, Vol 21, Iss 1, Pp 1-7 (2021)
ISSN:	1471-2253 1800-0193
Popis:	Background To investigate the effects of different plasma target concentrations of remifentanil on the minimum alveolar concentration (MAC) for blocking adrenergic response (BAR) of sevoflurane in children with laparoscopic herniorrhaphy. Methods Seventy-five children with 3-7 years old scheduled for laparoscopic herniorrhaphy were randomly divided into group R0, group R1, and group R2 according to different remifentanil plasma target concentration (0, 1, and 2 ngml-1), respectively. The MACBAR of sevoflurane was determined by the up-and-down and sequential method in each group. The concentrations of epinephrine and noradrenaline were also determined at corresponding time points. Results A total of 52 child patients were used among the anticipated 75 patients. In groups R0, R1, and R2, the MACBAR of sevoflurane was (3.29 ± 0.17) %, (2.12 ± 0.10) % and (1.29 ± 0.11) %, respectively, and a significant difference was found among the three groups (P Conclusion Remifentanil by target-controlled infusion can effectively reduce the MACBAR of sevoflurane during laparoscopic surgery in children. At a similar effect of MACBAR, both the changes of epinephrine and noradrenaline concentrations are not affected by the infusion of different remifentanil target concentrations. Trial registration The trial was registered at http://www.chictr.org.cn(ChiCTR1800019393, 8, Nov, 2018).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd1831d55a8b8964b772aad2c051566 https://doaj.org/article/680ee802b2a442d5b518d92bae7be891 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.