Serum levels of soluble IL-2 receptor, IL-4 and IgE-binding factors in childhood allergic diseases
| Autor: | T. Kawabe, K. Yamaguchi, T. Matsumoto, T. Miike, M. Murakami, J. Yodoi |
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| Rok vydání: | 1991 |
| Předmět: |
Interleukin 2
Allergy Adolescent Immunology Immunoglobulin E Immunopathology Hypersensitivity Humans Immunology and Allergy Medicine IL-2 receptor Child Interleukin 4 Asthma Lymphokines biology business.industry Age Factors Infant Prostatic Secretory Proteins Receptors Interleukin-2 medicine.disease Child Preschool biology.protein Interleukin-4 business Anaphylaxis Research Article medicine.drug |
| Zdroj: | Clinical and Experimental Immunology. 85:288-292 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARYThe serum levels of soluble IL-2 receptor (sIL-2R), IL-4 and IgE-binding factors were examined in children with allergic diseases, and compared with those in non-allergic controls of the same age and sex. The results showed age-related decreases in the serum levels of sIL-2R and IgE-binding factors, but not in that of IL-4 in both allergic and non-allergic individuals. Significant elevation of sIL-2R was observed in sera from children with atopic eczema or history of an anaphylactic reaction to food, as compared with that in non-allergic controls. The serum concentration of IL-4 was elevated in all allergic groups, including cases of atopic eczema, bronchial asthma and anaphylaxis to food, compared with non-allergic controls, and was correlated significantly with the serum level of IgE (r= 0.59). The IgE-binding factor levels in sera from patients aged 6-10 years with bronchial asthma, or patients aged 1-5 years with a history of food anaphylaxis were elevated as compared with those in non-allergic controls of same age. There was no significant correlation between the serum levels of IgE-binding factors and IgE. Since sIL-2R is released by activated T cells, the present study is in favour of T cell activation causing allergic skin disorders. The serum levels of IL-4 as well as IgE did not differ among allergic patients of different clinical categories. The role of IgE in atopic eczema and other allergic diseases is not clearly established; however, it seems likely that IL-4 is deeply involved in the increased production of IgE seen in allergic individuals. The possible involvement of IgE-binding factors in the age-related changes of clinical manifestations in childhood allergic diseases was also discussed. |
| Databáze: | OpenAIRE |
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