Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function
| Autor: | Zuzana Technikova-Dobrova, Damiano Panelli, Anna Signorile, Anna Maria Sardanelli, Salvatore Scacco, Raffaella Scaringi, Arcangela Santeramo, Francesco Papa, Giuseppe Palmisano, Domenico De Rasmo, Sergio Papa |
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| Rok vydání: | 2008 |
| Předmět: |
Models
Molecular Protein subunit Molecular Sequence Data Biophysics Biology Mitochondrion Biochemistry Serine Oxygen Consumption Oxidoreductase Complex I Cyclic AMP Animals Homeostasis Respiratory function PKA Amino Acid Sequence PRKAR1A Conserved Sequence Mammals chemistry.chemical_classification Electron Transport Complex I Mitochondrial import Sequence Homology Amino Acid NDUFS4 Cell Biology Proton pump Mitochondria Cell biology Kinetics chemistry cAMP cascade Mitochondrial phosphoproteome Phosphorylation |
| Zdroj: | (2008). info:cnr-pdr/source/autori:Sergio Papa, Domenico De Rasmo, Salvatore Scacco, Anna Signorile, Zuzana Technikova-Dobrova, Giuseppe Palmisano, Anna Maria Sardanelli, Francesco Papa, Damiano Panelli, Raffaella Scaringi and Arcangela Santeramo/titolo:Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function/doi:/rivista:/anno:2008/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| Popis: | In this paper the regulatory features of complex I of mammalian and human mitochondria are reviewed. In a variety of mitotic cell-line cultures, activation in vivo of the cAMP cascade, or direct addition of cAMP, promotes the NADH–ubiquinone oxidoreductase activity of complex I and lower the cellular level of ROS. These effects of cAMP are found to be associated with PKA-mediated serine phosphorylation in the conserved C-terminus of the subunit of complex I encoded by the nuclear gene NDUFS4. PKA mediated phosphorylation of this Ser in the C-terminus of the protein promotes its mitochondrial import and maturation. Mass-spectrometry analysis of the phosphorylation pattern of complex I subunits is also reviewed. |
| Databáze: | OpenAIRE |
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